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Homeoproteins in developing CNS : non-canonical aspects of their function /

by Artimagnella, Osvaldo (Osvaldo Basilio : Oswy) [aut]; Mallamaci, Antonio [ths]; Mercurio, Sara [opn].
Material type: materialTypeLabelBookPublisher: Catania : Scuola Superiore di Catania, 2015Description: 68 p. : ill. ; 25 cm.Subject(s): Cell physiology | Proteins
Contents:
Abstract -- Introduction -- Non-canonical activities of homeoproteins -- Theoretical and therapeutic implications -- Conclusions -- Bibliography -- Ringraziamenti.
Dissertation note: Tesi di diploma di 1° livello per la Classe delle Scienze Sperimentali Diploma di 1° livello Scuola Superiore di Catania, Catania, Italy 2015 A.A. 2014/2015 Abstract: Since their discovery in the fruitfly, the homeoproteins (HPs) were considered key players in the definition of body axis and cellular identity, as well as in the determination of morphology and physiology at cellular and multicellular levels. These functions were confirmed in vertebrates, where homologs of these proteins were early found. Here, it was classically assumed that HPs would act as transcription factors, according to a cell autonomous paradigm, which was experimentally con-firmed to large extent. However, more and more evidences have accumulated suggesting that HPs also act as translational factors and non-cell autonomous morphogens. These "non-canonical" HP activities are the subject of this thesis. Here, we refer to three HPs, Hoxd1, Engrailed, and Otx2, involved in the control of three key neurodevelopmental processes, which are the mesoderm-to-neuroectoderm transfer of antero-posterior information, retinotectal axon guidance, and the regulation of visual cortex plasticity, respectively. In our opinion, non-canonical activities of Hoxd1, Engrailed, and Otx2 are of paramount interest. They disclose new mechanistic neuro-developmental avenues. They point to novel evolutionary scenarios. They provide hints and useful suggestions for innovative therapeutic approaches.
List(s) this item appears in: Tesi di Laurea, Diploma, Dottorato, Master
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Location Call number Copy number Status Date due
THS_2015 573.864 A7916 (Browse shelf) 1 Available
THS_2015 573.864 A7916 (Browse shelf) 2 Available

Tesi di diploma di 1° livello per la Classe delle Scienze Sperimentali Diploma di 1° livello Scuola Superiore di Catania, Catania, Italy 2015 A.A. 2014/2015

Includes bibliographical references (p. 57-67).

Abstract -- Introduction -- Non-canonical activities of homeoproteins -- Theoretical and therapeutic implications -- Conclusions -- Bibliography -- Ringraziamenti.

Tesi discussa il 30/06/2015.

Since their discovery in the fruitfly, the homeoproteins (HPs) were considered key players in the definition of body axis and cellular identity, as well as in the determination of morphology and physiology at cellular and multicellular levels. These functions were confirmed in vertebrates, where homologs of these proteins were early found. Here, it was classically assumed that HPs would act as transcription factors, according to a cell autonomous paradigm, which was experimentally con-firmed to large extent. However, more and more evidences have accumulated suggesting that HPs also act as translational factors and non-cell autonomous morphogens. These "non-canonical" HP activities are the subject of this thesis. Here, we refer to three HPs, Hoxd1, Engrailed, and Otx2, involved in the control of three key neurodevelopmental processes, which are the mesoderm-to-neuroectoderm transfer of antero-posterior information, retinotectal axon guidance, and the regulation of visual cortex plasticity, respectively. In our opinion, non-canonical activities of Hoxd1, Engrailed, and Otx2 are of paramount interest. They disclose new mechanistic neuro-developmental avenues. They point to novel evolutionary scenarios. They provide hints and useful suggestions for innovative therapeutic approaches.

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