|Location||Call number||Copy number||Status||Date due|
|Sala B : Armadio Tesi||THS_2015 618.1 S784 (Browse shelf)||1||Available|
|Sala B : Armadio Tesi||THS_2015 618.1 S784 (Browse shelf)||2||Available|
Tesi di diploma (corsi di laurea a ciclo unico) per la Classe delle Scienze Sperimentali Diploma di 2° livello Scuola Superiore di Catania, Catania, Italy 2015 A.A. 2013/2014
Includes bibliographical references (p. 30-38) and index.
Abbreviations -- Introduction -- Experimental section -- Results -- Discussion -- References --
Nowadays it is known that healthy adolescent females presenting anovulatory cycles are characterized by higher androgen and gonadotropin concentrations, compared to ovulatory ones. These hormonal alterations represent typical manifestations of polycystic ovarian syndrome (PCOS). Recent studies have shown that in PCOS women, AMH and INSL3 levels are significantly higher than controls and correlate with anovulation and hyperandrogenism, respectively. These two peptide represent new markers of ovarian function. INSL3 is produced by the follicular theca interna cerlls and via its receptor, RXFP2, stimulates the production of the main androgen, androstenedione (A4), by the theca cells. AMH is produced by granulosa cells of preantral and small antral follicles and is involved in follicular cyclic recruitment which leads to growth of the dominant follicle. The aim of this study was to evaluate the circulating levels of AMH and INSL3 and their association with gonadotropin and ovarian steroid hormones in a group of forty healthy eumenorrheic adolescent females, aged 16-19 years, with regular menses and withour signs of hyperandrogenism divided into ovulatory and anovulatory subgroups in accordance with progesterone levels measured in the luteal phase. We demonstrated, for the first time, that anovulatory healthy female adolescents had higher AMH and INSL3 blood concentrations, in association with higher androgen levels, compared with age- and BMI-matched subjects with ovulatory cycle, suggesting evidence of an earlier ovarian dysfunction. However, additional studies are needed to determine whether these hormonal alterations are suggestive of hyperandrogenic condition later on, in adulthood.