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Twisting structure of amyloid fibrils emerges as a compromise between competing forces /

by Assenza, Salvatore, (PQ) [aut]; De Los Rios, P [ths].
Material type: materialTypeLabelBookPublisher: Catania : Scuola Superiore di Catania, 2011Description: 99 p. : ill. ; 30 cm.Subject(s): Protein folding. -- Mathematical models
Contents:
Introduction. Proteins in a nutshell. Amyloid fibrils: the general picture. Experimental results on beta-lactoglobulin fibrils. A simple model for amylod fibrils. Conclusions and future perspectives. Bibliography.
Dissertation note: Tesi di diploma di 2° livello per la Classe delle Scienze Sperimentali Diploma di 2° livello Scuola Superiore di Catania, Catania, Italy 2011 A.A. 2010/2011 Abstract: In this thesis, an original model is proposed in order to explain the results found in recent experimental works, where fibirls made of beta-lactoglobulin monomers were studied. In particular, the authors show that such fibrils are made of several inter-twisting filaments organized in a ribbon-like structure, thus showing a pitch, i.e. a period in length, which depends on the width of the ribbon and on the concentration of salt added in the solvent+fibrils solution. In the model, which is introduced and discussed in Chapter 4, the fibrils are described at a coarse-grained level, by considering each filament as a chain made of springs and charged beads put in an electrolyte solution, whose physics is implemented by using the Poisson-Boltzmann equation for surfaces. In spite of its simplicity, the model turns out not only to capture the physics of the system, but also to quantitatively describe the experimental data.
List(s) this item appears in: Tesi di Laurea, Diploma, Dottorato, Master | Complexity and chaos
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Sala B : Armadio Tesi THS_2011 572.622 A845 (Browse shelf) 1 Available

Tesi di diploma di 2° livello per la Classe delle Scienze Sperimentali Diploma di 2° livello Scuola Superiore di Catania, Catania, Italy 2011 A.A. 2010/2011

Includes bibliographical references (88-93 p.) and index.

Introduction. Proteins in a nutshell. Amyloid fibrils: the general picture. Experimental results on beta-lactoglobulin fibrils. A simple model for amylod fibrils. Conclusions and future perspectives. Bibliography.

In this thesis, an original model is proposed in order to explain the results found in recent experimental works, where fibirls made of beta-lactoglobulin monomers were studied. In particular, the authors show that such fibrils are made of several inter-twisting filaments organized in a ribbon-like structure, thus showing a pitch, i.e. a period in length, which depends on the width of the ribbon and on the concentration of salt added in the solvent+fibrils solution. In the model, which is introduced and discussed in Chapter 4, the fibrils are described at a coarse-grained level, by considering each filament as a chain made of springs and charged beads put in an electrolyte solution, whose physics is implemented by using the Poisson-Boltzmann equation for surfaces. In spite of its simplicity, the model turns out not only to capture the physics of the system, but also to quantitatively describe the experimental data.

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