|Location||Call number||Copy number||Status||Date due|
|Sala B : Armadio Tesi||THS_2012 572.622 A845 (Browse shelf)||1||Available|
Tesi di diploma di 2° livello per la Classe delle Scienze Sperimentali Diploma di 2° livello Scuola Superiore di Catania, Catania, Italy 2012 A.A. 2010/2011
Includes bibliographical references (p. 88-93).
Introduction -- Proteins in a nutshell -- Amyloid fibrils : the general picture -- Experimental results on beta-lactoglobulin fibrils -- A simple model for amylod fibrils -- Conclusions and future perspectives -- Bibliography.
Tesi discussa il 22/6/2012.
In this thesis, an original model is proposed in order to explain the results found in recent experimental works, where fibirls made of beta-lactoglobulin monomers were studied. In particular, the authors show that such fibrils are made of several inter-twisting filaments organized in a ribbon-like structure, thus showing a pitch, i.e. a period in length, which depends on the width of the ribbon and on the concentration of salt added in the solvent+fibrils solution. In the model, which is introduced and discussed in Chapter 4, the fibrils are described at a coarse-grained level, by considering each filament as a chain made of springs and charged beads put in an electrolyte solution, whose physics is implemented by using the Poisson-Boltzmann equation for surfaces. In spite of its simplicity, the model turns out not only to capture the physics of the system, but also to quantitatively describe the experimental data.