Biblioteca Allievi della Scuola Superiore di Catania

Contents:

Dissertation note: Tesi di diploma di 2° livello per la Classe delle Scienze Sperimentali Diploma di 2° livello Scuola Superiore di Catania, Catania, Italy 2012 A.A. 2010/2011 Abstract: In this thesis, an original model is proposed in order to explain the results found in recent experimental works, where fibirls made of beta-lactoglobulin monomers were studied. In particular, the authors show that such fibrils are made of several inter-twisting filaments organized in a ribbon-like structure, thus showing a pitch, i.e. a period in length, which depends on the width of the ribbon and on the concentration of salt added in the solvent+fibrils solution. In the model, which is introduced and discussed in Chapter 4, the fibrils are described at a coarse-grained level, by considering each filament as a chain made of springs and charged beads put in an electrolyte solution, whose physics is implemented by using the Poisson-Boltzmann equation for surfaces. In spite of its simplicity, the model turns out not only to capture the physics of the system, but also to quantitatively describe the experimental data.
Introduction -- Proteins in a nutshell -- Amyloid fibrils : the general picture -- Experimental results on beta-lactoglobulin fibrils -- A simple model for amylod fibrils -- Conclusions and future perspectives -- Bibliography.

Location | Call number | Copy number | Status | Date due |
---|---|---|---|---|

Sala B : Armadio Tesi | THS_2012 572.622 A845 (Browse shelf) | 1 | Available |

Tesi di diploma di 2° livello per la Classe delle Scienze Sperimentali Diploma di 2° livello Scuola Superiore di Catania, Catania, Italy 2012 A.A. 2010/2011

Includes bibliographical references (p. 88-93).

Introduction -- Proteins in a nutshell -- Amyloid fibrils : the general picture -- Experimental results on beta-lactoglobulin fibrils -- A simple model for amylod fibrils -- Conclusions and future perspectives -- Bibliography.

Tesi discussa il 22/6/2012.

In this thesis, an original model is proposed in order to explain the results found in recent experimental works, where fibirls made of beta-lactoglobulin monomers were studied. In particular, the authors show that such fibrils are made of several inter-twisting filaments organized in a ribbon-like structure, thus showing a pitch, i.e. a period in length, which depends on the width of the ribbon and on the concentration of salt added in the solvent+fibrils solution. In the model, which is introduced and discussed in Chapter 4, the fibrils are described at a coarse-grained level, by considering each filament as a chain made of springs and charged beads put in an electrolyte solution, whose physics is implemented by using the Poisson-Boltzmann equation for surfaces. In spite of its simplicity, the model turns out not only to capture the physics of the system, but also to quantitatively describe the experimental data.